The cat allergy is arguably the saddest development for cat lovers. The moment you come in contact with the cat, you start to sneeze, experience runny nose, itchy eyes, skin rashes, and even have asthma problems.
Cat allergies affect one in ten people, which is a significant number. Cat allergies affect as much as 30% of the population in some places.
Many people who claim to be cat slaves insist on owning cats while suffering from allergies. Some people, on the other hand, are forced to euthanize their cats because they or members of their family suffer from severe allergies. It hurts in both cases.
Contrary to popular belief, cat fur is not the problem. The primary allergen is a protein called Fel d 1 that is released by the sebaceous and salivary glands of cats. This protein, which cats lick all over their bodies, adheres to carpets, curtains, bed sheets, people's hair, and clothing, and is released into the air through dander and hair. Even after a thorough cleanup, felt d 1 is challenging to get rid of due of its extreme stickiness. Most people can benefit from finding an anti-allergic treatment that targets Fel d 1.
Through immune control mechanisms, allergen-specific immunotherapy (AIT), a treatment that promotes tolerance, alters the course of allergic disorders.
Recently, researchers from the Luxembourg Institute of Health explained in an article published in the journal Allergy under the title "Comprehensive mapping of immune tolerance yields a regulatory TNF receptor 2 signature in a murine model of successful Fel d 1-specific immunotherapy using high-dose" that high-dose specific adjuvant molecules CpG oligonucleotides can modify the immune system's allergic response to the major cat allergen Fel d 1, thereby promoting human tolerance.
The ability of humans to endure the highest CpG dose in endotoxin-free conditions was assessed after researchers built a BALB/c OlaHsd mice efficacy model allergic to Fel d 1 in order to study the clinical effect of high-dose CpG adjuvant AIT. It was discovered that the allergic mice treated with AIT showed lower IgE levels and higher IgA and IgG (anti-inflammatory effects), and the lung function and respiratory tract inflammation were obviously improved. This was done by detecting the Fel d 1 specific antibodies in the serum of the mice.
The levels of pro-allergic cytokines in mice treated with AIT were found to be lower than those in untreated allergic mice when the researchers looked further into the cytokines in mouse bronchoalveolar lavage fluid (BALF). This demonstrates how AIT can lessen bronchial hyperresponsiveness and airway inflammation in a preclinical setting.
The researchers also observed that a significant number of immune cells involved in allergy regulation and tolerance, such as regulatory T cells (T-regs), regulatory B cells (B-regs), natural killer cells (NKs), plasmacytoid dendritic cells (pDC), and regulatory T cells (T-regs), expressed high levels of tumor necrosis factor (TNF-), tumor necrosis factor receptor (TNFR-2), and act as a "brake" on the immune system.
The researchers also discovered that AIT activates a novel Treg dubbed biTreg, which can balance effector cells' responses to antigens. This underlines the anti-allergic impact of AIT and the reversibility of allergic features.
In order to translate these findings into clinical practice, scientists have created a subcutaneous (sc) injection medication delivery technique that is more efficient than conventional intraperitoneal (IP) injection at reducing the amount of airway eosinophils and inhibiting the Th2 immune response.
The researchers created a medically acceptable mode of delivery and optimized the ATI specific therapy for cat allergy based on the highest CpG dose that humans could take, setting the groundwork for the creation of novel allergic immunotherapy.
In addition to AIT, researchers are still developing alternative strategies.
1. Vaccinate cats to stop them from developing fel d 1.
2. Through the cat food, the antibodies that neutralize allergens are immediately injected into the cat's body.
Leave a Reply
Related Products
You Might Like Also
On January 6, 2023, lecanemab (trade name Leqembi), an Alzheimer's disease drug developed by Eisai and Biogen, received conditional approval from the FDA. The results of its Phase 3 clinical trial showed that the drug slowed cognitive decline in Alzheimer's disease patients by 27%. The FDA has conducted a further review of the clinical trial results to determine whether the drug can be fully approved. Read More
Therapeutic antibodies, engineered through biotechnology, represent a specialized class of antibodies used in disease treatment. These antibodies are designed to target specific disease markers, such as malignant tumors, autoimmune disorders, and infectious diseases. Compared to traditional antibody therapies, therapeutic antibodies offer higher specificity and fewer side effects. Read More
Summer's Invisible Killer—Mosquitoes
As summer unfolds in the year 2023, people will contend with not only scorching temperatures but also the constant annoyance of mosquitoes buzzing around and biting at every opportunity. The combination of high temperatures and factors such as food spoilage creates an ideal breeding ground for mosquitoes, making them a prominent threat during the summer months. Read More
Antibodies, the extraordinary proteins that serve as the frontline troops of the human immune system, have recently gained attention for their ability to combat tiny compounds known as haptens. Because of their small size, these elusive targets present particular difficulty for the immune system to identify as foreign invaders. However, researchers' inventiveness has resulted in the creation of several techniques to bypass this barrier and unleash the full potential of hapten antibodies. Read More
The COVID-19 pandemic, which emerged at the end of 2019, may have receded from public consciousness, but its impact continues to reverberate. Over the past three years, countries worldwide have grappled with multiple waves of widespread infection. Although many nations have now established immunity barriers, the risk of long COVID symptoms and recurrent infections still looms large. Such repeated infections could have a profound effect on individuals' immune function. Read More
The realm of biopharmaceuticals plays a crucial role in modern medical treatment, yet faces significant challenges. A notable concern is the brief half-life of many biopharmaceutical products, leading to swift degradation and clearance from the patient's body, necessitating frequent dosing. This article delves into the ways in which half-life extension strategies in drug development can effectively tackle this issue, enhancing patient convenience and optimizing therapeutic outcomes. Read More
